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Section for healthcare professionals and other qualified operators only. This section contains information about in vitro diagnostic medical devices and is intended exclusively for healthcare professionals and other qualified operators under the applicable rules. By proceeding, you declare that you are a healthcare professional or an equivalent qualified operator and acknowledge that these contents are not intended for the general public.

VERIGENE® NanoGrid Technology

NanoGrid Technology is the powerful driving force behind all VERIGENE tests

The VERIGENE® System utilizes automation and proprietary chemistry to enable rapid, sample-to-result detection of nucleic acid and protein targets. NanoGrid Technology, a unique gold nanoparticle probe chemistry, is the driving force behind all VERIGENE tests, providing a versatile and extremely reliable foundation for the VERIGENE® System.

NanoGrid Technology

How does NanoGrid Technology work?

The gold nanoparticles are 13-20 nanometers in diameter. Each nanoparticle is functionalized with either a defined number of oligonucleotides or antibodies that are specific to a particular protein of interest.

VERIGENE® NanoGrid Technology benefits

The VERIGENE® System using NanoGrid technology entails

  • Nucleic acid extraction and PCR amplification
  • Hybridization of target DNA on a microarray
  • Hybridization of specific mediator oligonucleotides and gold nanoparticle probes
  • Signal amplification of hybridized probes via a silver staining process
  • Automated qualitative analysis of results

Gold nanoparticle probes are ideal for diagnostic applications

  • Allow increased sensitivity by several orders of magnitude compared to fluorophores. 
  • Enable high-specificity for both nucleic acid and protein detection
  • Reduce background noise, creating an enhanced assay signal
  • Are extremely stable, have a long shelf-life, and are non-toxic

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