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VERIGENE® NanoGrid Technology

NanoGrid Technology is the powerful driving force behind all VERIGENE tests

The VERIGENE® System utilizes automation and proprietary chemistry to enable rapid, sample-to-result detection of nucleic acid and protein targets. NanoGrid Technology, a unique gold nanoparticle probe chemistry, is the driving force behind all VERIGENE tests, providing a versatile and extremely reliable foundation for the VERIGENE® System.

NanoGrid Technology

How does NanoGrid Technology work?

The gold nanoparticles are 13-20 nanometers in diameter. Each nanoparticle is functionalized with either a defined number of oligonucleotides or antibodies that are specific to a particular protein of interest.

VERIGENE® NanoGrid Technology benefits

The VERIGENE® System using NanoGrid technology entails

  • Nucleic acid extraction and PCR amplification
  • Hybridization of target DNA on a microarray
  • Hybridization of specific mediator oligonucleotides and gold nanoparticle probes
  • Signal amplification of hybridized probes via a silver staining process
  • Automated qualitative analysis of results

Gold nanoparticle probes are ideal for diagnostic applications

  • Allow increased sensitivity by several orders of magnitude compared to fluorophores. 
  • Enable high-specificity for both nucleic acid and protein detection
  • Reduce background noise, creating an enhanced assay signal
  • Are extremely stable, have a long shelf-life, and are non-toxic


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