Cytochrome P450 2C19 (CYP2C19) metabolize 5% of the prescription drugs in use today. Genotypic variants of CYP2C19 change how these drugs are metabolized. CYP2C19*2 and CYP2C19*3 variants account for approximately 99% of Asian and 87% of Caucasians poor metabolizers, respectively. Over one-third of Caucasians and over 40% of patients of African and Asian ancestry harbor gain-of-function and loss-of-function 2C19 variants. These variants are linked to a higher risk of adverse events with certain drugs.
CYP2C19 mutations are potential indicators of poor drug metabolism
The value of xTAG® CYP2C19 Kit v3
Empower clinicians to accurately identify clinically relevant CYP2C19 mutations: CYP2C19*2, CYP2C19*3, and CYP2C19*17.
Detect and identify clinically relevant genotypes.
Obtain flexibility in throughput with Luminex® 200™ platform and MAGPIX® instrument.
Gain confidence in results with high accuracy and reproducibility.
How the xTAG® CYP2C19 Kit v3 test works
xTAG® CYP2C19 Kit v3 is a multiplexed nucleic acid test intended for the detection of clinically relevant mutations *2, *3, *17.
High complexity workflow
Nucleic acid extraction and purification, multiplex amplification, bead hybridization and detection, and data acquisition and analysis by MAGPIX® or Luminex® 200™ with xPONENT® software.
Time to results
Within 8 hours, a laboratory can detect and determine the relevant genotypes for their clients.
xTAG® CYP2C19 Kit v3
The xTAG® CYP2C19 is multiplex PCR and multiplex Allele Specific Primer Extension (ASPE) on Luminex platforms that automatically determines diplotype.
For use with the MAGPIX® or Luminex® 200™ Systems with xPONENT®
xTAG® CYP2C19 Kit v3 Test rapidly and accurately detects relevant mutations via the MAGPIX® or Luminex® 200TM systems with xPONENT® software.
Delivery of this time-critical information allows clinicians to provide targeted patient care more quickly.
xTAG® CYP2C19 Kit v3 Test makes it a valuable system for use in specialized laboratories with high-complexity testing capabilities.
xTAG® CYP2C19 Kit v3 ordering info
xTAG® CYP2C19 Kit v3